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Ps and Hs caluculation (M.Matsuda and R.A.DeFronzo, 1997) For PC user or Windows users To download PC program to calculate Ps and Hs from euglycemic insulin clamp data please click here. (gcix.exe 272 KB created in 1997) For previous Mac users (OS-9 based) To download old Mac program to calculate Ps and Hs from euglycemic insulin clamp data please click here. (Gcix.exe_for_Mac) 81.5 KB created in 1997) This program allows you to separate peripheral (Ps) and hepatic (Hs) insulin sensitivity from euglycemic clamp data conducted without tracer. Reference Matsuda M, Lee N, Shank M, DeFronzo RA: Isolation of Hepatic and Peripheral Insulin Sensitivity: Application to the Investigation of Inherited or Acquired Defects in NIDDM. Diabetes 45 (suppl. 1): 17A, 1996 Modification of Homeostatic Model Assessment Use of actual data from our laboratory to construct the dose response relationship between plasma insulin conc versus HGP and peripheral glucose uptake Use of actual data from our laboratory to construct the dose response relationship relating plasma glucose conc versus HGP and peripheral glucose uptake Allow hepatic and peripheral sensitivity to insulin to vary independently Utilize the basal plasma glucose and insulin concentrations, as well as the steady state plasma glucose and insulin concentrations during the euglycemic insulin clamp